On the link between cholesterol and cancer incidence
High cholesterol levels associated with lowered cancer risk
by copyright © 2017 Healing Cancer Naturally
While previous studies into the question had yielded somewhat conflicting data, new research seems to point to cholesterol, the much vilified though essential lipid molecule of the human body definitely boasting cancer-preventative and protective properties.
A recent (2013) large-scale study involving over half a million Europeans (who were followed for an average of some twelve years) demonstrated some astounding associations between "high cholesterol" and reduced cancer risk. While with some types of cancer no significant relationship could be established either way, high total serum cholesterol levels were significantly associated with lowered cancer risk in females as well as several specific malignancies in both sexes (the one exception regarding the positive role of high cholesterol as a "cancer-preventative" was colon cancer in males).
Women with the highest cholesterol levels showed an overall reduction in all types of cancer of 14%. Neoplasms involving the gallbladder actually showed a whopping 77% reduction, melanoma, leukemia and lymphoma were lowered by 39%, and the incidence of breast cancer by 30%.
Similarly, men with the highest cholesterol levels showed an amazing 86% reduction in liver cancer as well as cancer of the intrahepatic bile ducts, a 48% lower incidence of pancreatic cancer, 33% of skin cancer (melanoma excepted) and 32% of lymphoma and leukemia.
French researchers recently found what appears to be an important pointer to the reason why high cholesterol may exert a cancer-protective effect. They identified a hitherto unknown metabolite of cholesterol (i.e. a molecule derived from cholesterol) they named Dendrogenin A (DDA). The scientists showed DDA to have tumour-suppressing effects on both cell lines and tumors (breast cancer and melanoma) implanted in mice, triggering the redifferentiation of malignant cells. While Dendrogenin A can be found in normal tissue, it is absent or its levels are lowered in cancer tumors. Among other properties found, DDA astoundingly was seen to restore hearing in a preclinical model of deafness.
1 See simplified background on the cholesterol issue under Budwig FAQ Question 75 re cholesterol level.
2 "Total serum cholesterol and cancer incidence in the Metabolic syndrome and Cancer Project (Me-Can)", published in PLoS One in 2013 (www.ncbi.nlm.nih.gov/pubmed/23372693). The study can be read in its entirety at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054242
4 Healing Cancer Naturally does not support animal experimentation.
5 See the studies "Dendrogenin A: A Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties" published in Current Medicinal Chemistry in 2015 (www.ncbi.nlm.nih.gov/pubmed/26179999) and "When cholesterol meets histamine, it gives rise to dendrogenin A: a tumour suppressor metabolite" printed in Biochemical Society Transactions in 2016 (www.ncbi.nlm.nih.gov/pubmed/27068981).
With thanks to the French newsletter "Neo-nutrition : La lettre de la nutritherapie" published by www.santenatureinnovation.com.